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Cd44tm1Stpa
Targeted Allele Detail
Summary
Symbol: Cd44tm1Stpa
Name: CD44 antigen; targeted mutation 1, Steven T Pals
MGI ID: MGI:5544103
Synonyms: Cd44v4-10
Gene: Cd44  Location: Chr2:102641486-102732010 bp, - strand  Genetic Position: Chr2, 54.13 cM
Alliance: Cd44tm1Stpa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204874
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe targeting construct introduced a partial cDNA encoding constant region 5, splicing variant v4-10 and constant regions 16-20 followed by an IRES, lacZ gene and hygromycin resistance cassette. (J:204874)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  67 strains or lines available
References
Original:  J:204874 Zeilstra J, et al., Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene. 2014 Jan 30;33(5):665-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory