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Edn2tm1.2Nat
Targeted Allele Detail
Nomenclature
Symbol: Edn2tm1.2Nat
Name: endothelin 2; targeted mutation 1.2, Jeremy Nathans
MGI ID: MGI:5544096
Gene: Edn2  Location: Chr4:120161206-120167360 bp, + strand  Genetic Position: Chr4, 55.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201133
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe second exon was flanked by two LoxP sites and an FRT flanked neo cassette was inserted. Recombinase mediated recombination removed the selection cassette and exon 2. (J:158269, J:201133)
Generation of the Edn2tm1.2Nat allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edn2 Mutation:  11 strains or lines available
References
Original:  J:201133 Rattner A, et al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory