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Tg(Amh-SMAD2*)#Jebu
Transgene Detail
Summary
Symbol: Tg(Amh-SMAD2*)#Jebu
Name: transgene insertion, Joanna E Burdette
MGI ID: MGI:5543909
Synonyms: Smad2DN
Transgene: Tg(Amh-SMAD2*)#Jebu  Location: unknown  
Alliance: Tg(Amh-SMAD2*)#Jebu page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Amh-SMAD2*)#Jebu expresses 1 gene
 
Mutation detailsThis transgene consists of a mouse minimal Mullerian-inhibiting substance promoter (-180 bp), an epitope Flag tag, a C-terminal truncation of the human Smad2 gene resulting in a dominant negative effect, and a human GH polyadenylation sequence. The Amh promoter drives transgene expression in testicular Sertoli cells and ovarian granulosa cells. (J:200783)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:200783 Quartuccio SM, et al., Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas. PLoS One. 2013;8(5):e65067
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory