Ehmt1^tm2Yshk
Targeted Allele Detail

Summary

• Symbol: Ehmt1^tm2Yshk
• Name: euchromatic histone methyltransferase 1; targeted mutation 2, Yoichi Shinkai
• MGI ID: MGI:5543772
• Synonyms: GLP^CA, GLP^flox
• Gene: Ehmt1 Location: Chr2:24680781-24809658 bp, - strand Genetic Position: Chr2, 16.73 cM
• Alliance: Ehmt1^tm2Yshk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204470
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: Most of the reading frame was replaced by a loxP site, cDNA with a nucleotide substitution results in the amino acid substitution of alanine for cysteine at position 1201 (C1201A) in the methyltransferase-dead SET-domain, IRES, neomycin resistance cassette and a loxP site. The mutation abolishes enzymatic activity but does not affect heterodimerization with Ehmt2. (J:204470)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehmt1 Mutation: 90 strains or lines available

References

• Original: J:204470 Inagawa M, et al., Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
• All: 1 reference(s)