Dbi^tm2.2Smdp
Targeted Allele Detail

Summary

• Symbol: Dbi^tm2.2Smdp
• Name: diazepam binding inhibitor; targeted mutation 2.2, Susanne Mandrup
• MGI ID: MGI:5538737
• Gene: Dbi Location: Chr1:120041010-120048808 bp, - strand Genetic Position: Chr1, 52.65 cM, cytoband E2
• Alliance: Dbi^tm2.2Smdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed pgk-neo cassettte was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and exon 2. Protein level of ACBP was absent from keratinocytes in epidermis at day 21. (J:204137)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbi Mutation: 23 strains or lines available

References

• Original: J:204137 Neess D, et al., Delayed Hepatic Adaptation to Weaning in ACBP(-/-) Mice Is Caused by Disruption of the Epidermal Barrier. Cell Rep. 2013 Dec 12;5(5):1403-12
• All: 1 reference(s)