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Tbx3tm3.1Moon
Targeted Allele Detail
Nomenclature
Symbol: Tbx3tm3.1Moon
Name: T-box 3; targeted mutation 3.1, Anne M Moon
MGI ID: MGI:5538564
Synonyms: Tbx3flox
Gene: Tbx3  Location: Chr5:119670669-119684724 bp, + strand  Genetic Position: Chr5, 60.34 cM
Atrioventricular block in tamoxifen treated Tbx3tm3.1Moon/Tbx3tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxA1 site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxA1 site was inserted upstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:179977)
Generation of the Tbx3tm1.1Moon, Tbx3tm2Moon, Tbx3tm2.1Moon, Tbx3tm3.1Moon, and Tbx3tm3.2Moon alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:  15 strains or lines available
References
Original:  J:179977 Frank DU, et al., Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E154-63
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory