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Targeted Allele Detail
Symbol: Tbx3tm3.1Moon
Name: T-box 3; targeted mutation 3.1, Anne M Moon
MGI ID: MGI:5538564
Synonyms: Tbx3flox
Gene: Tbx3  Location: Chr5:119670669-119684724 bp, + strand  Genetic Position: Chr5, 60.34 cM
Atrioventricular block in tamoxifen treated Tbx3tm3.1Moon/Tbx3tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:179977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxA1 site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxA1 site was inserted upstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:179977)
Generation of the Tbx3tm1.1Moon, Tbx3tm2Moon, Tbx3tm2.1Moon, Tbx3tm3.1Moon, and Tbx3tm3.2Moon alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:  15 strains or lines available
Original:  J:179977 Frank DU, et al., Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E154-63
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory