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Targeted Allele Detail
Symbol: Ank3tm2.1Bnt
Name: ankyrin 3, epithelial; targeted mutation 2.1, Vann Bennett
MGI ID: MGI:5538265
Synonyms: AnkGfl
Gene: Ank3  Location: Chr10:69533580-70027436 bp, + strand  Genetic Position: Chr10, 36.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:198370
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 23. Flp-mediated recombination removed the neomycin resistance cassette and left exons 22 and 23 floxed. (J:198370)
Schematic of the Ank3tm2.1Bnt and Ank3tm2.2Bnt alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ank3 Mutation:  5 strains or lines available
Original:  J:198370 Jenkins PM, et al., E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. J Biol Chem. 2013 May 17;288(20):14018-31
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory