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Ank3tm2.1Bnt
Targeted Allele Detail
Nomenclature
Symbol: Ank3tm2.1Bnt
Name: ankyrin 3, epithelial; targeted mutation 2.1, Vann Bennett
MGI ID: MGI:5538265
Synonyms: AnkGfl
Gene: Ank3  Location: Chr10:69533580-70027436 bp, + strand  Genetic Position: Chr10, 36.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198370
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 23. Flp-mediated recombination removed the neomycin resistance cassette and left exons 22 and 23 floxed. (J:198370)
Schematic of the Ank3tm2.1Bnt and Ank3tm2.2Bnt alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ank3 Mutation:  5 strains or lines available
References
Original:  J:198370 Jenkins PM, et al., E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. J Biol Chem. 2013 May 17;288(20):14018-31
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory