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Targeted Allele Detail
Symbol: Sidt2tm1.1Hzha
Name: SID1 transmembrane family, member 2; targeted mutation 1.1, Huiwen Zhang
MGI ID: MGI:5532825
Gene: Sidt2  Location: Chr9:45937857-45955258 bp, - strand  Genetic Position: Chr9, 25.36 cM
Increase in body size of Sidt2tm1.1Hzha/Sidt2tm1.1Hzha adult mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:204228
Parent Cell Line:  PRX-129S6 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2, but left the FRT-flanked neomycin resistance cassette intact. Western blot analysis confirmed decreased protein expression in the liver. (J:204228)
Generation of the Sidt2tm1.1Hzha allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sidt2 Mutation:  29 strains or lines available
Original:  J:204228 Gao J, et al., Impaired glucose tolerance in a mouse model of sidt2 deficiency. PLoS One. 2013;8(6):e66139
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory