Hsd11b1^tm1.2Tuck
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1.2Tuck
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1.2, David Tucker
• MGI ID: MGI:5532495
• Gene: Hsd11b1 Location: Chr1:192903948-192946353 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1.2Tuck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203302
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed the floxed exon 2 and the neomycin resistance cassette. (J:203302)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 27 strains or lines available

References

• Original: J:203302 Harno E, et al., 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11beta-HSD1 is knocked out in livers of male mice. Endocrinology. 2013 Oct;154(10):3599-609
• All: 1 reference(s)