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Hltftm1.2Geno
Targeted Allele Detail
Summary
Symbol: Hltftm1.2Geno
Name: helicase-like transcription factor; targeted mutation 1.2, Genoway
MGI ID: MGI:5532313
Gene: Hltf  Location: Chr3:20111975-20172654 bp, + strand  Genetic Position: Chr3, 6.15 cM
Alliance: Hltftm1.2Geno page
Widespread vacuolation in the anteriorcommissure, preoptic/ventral palladium, and motor cortex of Hltftm1.2Geno/Hltftm1.2Geno neonatal brains

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203735
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 11 and 12. Western blot analysis confirmed the absence of protein expression in the heart, lung, liver, kidney and spleen. (J:203735)
Generation of the Hltftm1.2Geno allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hltf Mutation:  47 strains or lines available
References
Original:  J:203735 Helmer RA, et al., Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain. PLoS One. 2013;8(6):e66799
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory