Itgb1^tm14.1Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm14.1Ref
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 14.1, Reinhard Fassler
• MGI ID: MGI:5529145
• Synonyms: beta1 Y795A
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm14.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185558
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution(s) result(s) in the amino acid substitution of an alanine for tyrosine at position 795 (Y795A). Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:185558, J:203018)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 59 strains or lines available

References

• Original: J:185558 Bottcher RT, et al., Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol. 2012 Jun;14(6):584-92
• All: 2 reference(s)