Atoh7^{tm1.1(Ascl1)Nlbr}
Targeted Allele Detail

Summary

• Symbol: Atoh7^{tm1.1(Ascl1)Nlbr}
• Name: atonal bHLH transcription factor 7; targeted mutation 1.1, Nadean L Brown
• MGI ID: MGI:5529126
• Synonyms: Atoh7^Ascl1KI
• Gene: Atoh7 Location: Chr10:62935564-62937059 bp, + strand Genetic Position: Chr10, 32.54 cM
• Alliance: Atoh7^{tm1.1(Ascl1)Nlbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203642
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector replaced to coding sequence with the Ascl1 cDNA, IRES and DsRed2. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted downstream of the reporter gene. (J:203642)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh7 Mutation: 9 strains or lines available

References

• Original: J:203642 Hufnagel RB, et al., Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May;54:108-20
• All: 1 reference(s)