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Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Darren Moore
MGI ID: MGI:5527542
Synonyms: R26-LRRK2
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo expresses 1 gene
 
Mutation detailsThe targeting vector contains a SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a full-length human leucine-rich repeat kinase 2 cDNA bearing a familial Parkinson's disease-linked missense mutation R1441C, and a bovine polyadenylation signal. (J:101977)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  572 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory