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Tg(Alb-Mut)#Cpv
Transgene Detail
Nomenclature
Symbol: Tg(Alb-Mut)#Cpv
Name: transgene insertion, Charles P Venditti
MGI ID: MGI:5527452
Synonyms: TgINS-Alb-Mut
Transgene: Tg(Alb-Mut)#Cpv  Location: unknown  
Enlarged mitochondria with whorl-like cristae in Mmuttm1Cpv/Mmuttm1Cpv Tg(Alb-Mut)#Cpv/0 mice fed a high-protein diet

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Alb-Mut)#Cpv expresses 1 gene
 
Mutation detailsThis transgene construct contains a 2.25 kb murine Mut cDNA under the control of an alpha-fetoprotein enhancer and murine minimal albumin promoter cloned between two full-length tandem repeated chromatin barrier [hypersensitive site 4 from the chicken beta-globin cluster locus control region (cHS4)] insulator elements. Three founder lines were established. This represents the lowest expressing line. The pound symbol (#) is used because the line number is not specified. (J:200689)
Schematic of the Tg(Alb-Mut)#Cpv transgene
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:200689 Manoli I, et al., Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13552-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory