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Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz
Transgene Detail
Summary
Symbol: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz
Name: transgene insertion 2239, Jean J Zhao
MGI ID: MGI:5526971
Synonyms: HR-2239, TetOp-HA-PIK3CA-H1047R-luciferase, TetO-PIK3CAH1047R
Transgene: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz  Location: unknown  
Alliance: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz expresses 1 gene
 
Mutation detailsThe human PIK3CA cDNA with an amino acid substitution of arginine for histidine at position 1047 (H1047R) and an IRES-luciferase reporter are under the control of a tetracycline-inducible promoter. Two lines were generated, HR-2239 and HR-2251. (J:175839)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:175839 Liu P, et al., Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med. 2011;17(9):1116-20
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory