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Gabrdtm1.1Jmag
Targeted Allele Detail
Nomenclature
Symbol: Gabrdtm1.1Jmag
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta; targeted mutation 1.1, Jamie Maguire
MGI ID: MGI:5526859
Gene: Gabrd  Location: Chr4:155384979-155398098 bp, - strand  Genetic Position: Chr4, 86.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203336
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a FRT site flanked PGK-NEO cassette and a loxP site was inserted into exon 6 of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 5 and a portion of exon 6 floxed. (J:203336)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrd Mutation:  7 strains or lines available
References
Original:  J:203336 Lee V, et al., Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 2013 Dec;110(11):2520-35
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory