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Transgene Detail
Symbol: Tg(Actb-KRAS*G12V,-luc)#Lche
Name: transgene insertion, Lukas C Heukamp
MGI ID: MGI:5526090
Synonyms: RASLO
Transgene: Tg(Actb-KRAS*G12V,-luc)#Lche  Location: unknown  
Strain of Origin:  (C57BL/6 x FVB/N)F1
Transgene Type:    Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Tg(Actb-KRAS*G12V,-luc)#Lche expresses 1 gene
Mutation detailsA transgene consisting of a 1.8 kb chicken beta-actin promoter, a floxed STOP codon, a mutated KRASVAL12, a polyoma virus internal ribosomal re-entry site, and a fusion molecule consisting of chicken ovalbumin, an S-tag and a luciferase molecule. Expression of the constitutively active oncogenic KRASV12 is dependent on Cre-mediated deletion of the STOP codon. The pound symbol (#) is used because a line number was not specified. (J:199528)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:199528 Konig K, et al., Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One. 2013;8(3):e57996
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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