Kit^Wps
Chemically induced Allele Detail

Summary

• Symbol: Kit^Wps
• Name: KIT proto-oncogene receptor tyrosine kinase; wps
• MGI ID: MGI:5523955
• Synonyms: c-Kit^wps, Kit^D60N, Wps
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^Wps page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transversion in exon 2 that results in the amino acid substitution of arginine for aspartic acid at position 60 (D60N). (J:196572)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 179 strains or lines available

References

• Original: J:196572 Guo XL, et al., Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit. Pigment Cell Melanoma Res. 2010 Apr;23(2):252-62
• All: 3 reference(s)