Hsd17b4^tm2Baes
Targeted Allele Detail

Summary

• Symbol: Hsd17b4^tm2Baes
• Name: hydroxysteroid (17-beta) dehydrogenase 4; targeted mutation 2, Myriam Baes
• MGI ID: MGI:5523923
• Synonyms: Mfp2^loxP
• Gene: Hsd17b4 Location: Chr18:50261268-50329336 bp, + strand Genetic Position: Chr18, 27.24 cM
• Alliance: Hsd17b4^tm2Baes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201698
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 8 was floxed. A neomycin resistance cassette was inserted downstream of exon 8. (J:201698)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsd17b4 Mutation: 50 strains or lines available

References

• Original: J:201698 Verheijden S, et al., Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation. Neurobiol Dis. 2013 Oct;58:258-69
• All: 9 reference(s)