Ccdc88b^m1Pgrs
Chemically induced Allele Detail

Summary

• Symbol: Ccdc88b^m1Pgrs
• Name: coiled-coil domain containing 88B; mutation 1, Philippe Gros
• MGI ID: MGI:5523920
• Synonyms: Deric
• Gene: Ccdc88b Location: Chr19:6821991-6835579 bp, - strand Genetic Position: Chr19, 5.08 cM
• Alliance: Ccdc88b^m1Pgrs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C mutation in the splice donor consensus site of exon 21; Chr19: 6,848,180 (- strand) (build NCBI38/mm10). The point mutation results in a 5 nt deletion in the transcript and a frame-shift with a predicted premature termination at codon 1286. Western blot analysis confirmed the absence of protein expression in the spleen, thymus, lymph nodes and kidney. (J:230618)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc88b Mutation: 71 strains or lines available

References

• Original: J:230618 Kennedy JM, et al., CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med. 2014 Dec 15;211(13):2519-35
• All: 3 reference(s)