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Scn1atm2.2Kzy
Targeted Allele Detail
Nomenclature
Symbol: Scn1atm2.2Kzy
Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 2.2, Kazuhiro Yamakawa
MGI ID: MGI:5523788
Synonyms: Scn1ad
Gene: Scn1a  Location: Chr2:66270781-66440837 bp, - strand  Genetic Position: Chr2, 39.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202863
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/Ola
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Floxed exon 7 was deleted in all tissues by crossing animals to EIIa-cre mice. (J:202863)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1a Mutation:  72 strains or lines available
References
Original:  J:202863 Ogiwara I, et al., Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet. 2013 Dec 1;22(23):4784-804
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory