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Pappatm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Pappatm1Lex
Name: pregnancy-associated plasma protein A; targeted mutation 1, Lexicon Genomics
MGI ID: MGI:5523410
Synonyms: fPAPP-A
Gene: Pappa  Location: Chr4:65124174-65357509 bp, + strand  Genetic Position: Chr4, 34.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201775
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:201775)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pappa Mutation:  3 strains or lines available
References
Original:  J:201775 Conover CA, et al., Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response. Endocrinology. 2013 Aug;154(8):2734-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory