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Abhd5tm1.1Lqyu
Targeted Allele Detail
Summary
Symbol: Abhd5tm1.1Lqyu
Name: abhydrolase domain containing 5; targeted mutation 1.1, Liqing Yu
MGI ID: MGI:5523003
Synonyms: CGI-58f
Gene: Abhd5  Location: Chr9:122180681-122210589 bp, + strand  Genetic Position: Chr9, 73.03 cM, cytoband F4
Alliance: Abhd5tm1.1Lqyu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199570
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:199570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Abhd5tm1.1Lqyu
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abhd5 Mutation:  20 strains or lines available
References
Original:  J:199570 Guo F, et al., Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res. 2013 Aug;54(8):2109-20
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory