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Sdhbtm1.1Ics
Targeted Allele Detail
Nomenclature
Symbol: Sdhbtm1.1Ics
Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip); targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5521531
Synonyms: Sdhblox
Gene: Sdhb  Location: Chr4:140961271-140979198 bp, + strand  Genetic Position: Chr4, 73.24 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199113
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:199113)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdhb Mutation:  17 strains or lines available
References
Original:  J:199113 Letouze E, et al., SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell. 2013 Jun 10;23(6):739-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory