Lrrtm4^tm1Amcr
Targeted Allele Detail

Summary

• Symbol: Lrrtm4^tm1Amcr
• Name: leucine rich repeat transmembrane neuronal 4; targeted mutation 1, Ann Marie Craig
• MGI ID: MGI:5521326
• Gene: Lrrtm4 Location: Chr6:79995860-80787124 bp, + strand Genetic Position: Chr6, 35.05 cM
• Alliance: Lrrtm4^tm1Amcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201655
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 has been replaced with a LoxP site and a FRT flanked neo cassette. Western blot analysis of whole brain homogenates and confocal analysis of brain slices confirmed the absence of expression in homozygous mice. (J:201655)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrtm4 Mutation: 29 strains or lines available

References

• Original: J:201655 Siddiqui TJ, et al., An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. Neuron. 2013 Aug 21;79(4):680-95
• All: 3 reference(s)