About   Help   FAQ
Transgene Detail
Symbol: Tg(Thy1-Tcf4)1Mjro
Name: transgene insertion 1, Moritz J Rossner
MGI ID: MGI:5521185
Synonyms: Tcf4tg, Tg[Thy-1-Tcf4]1Mr
Transgene: Tg(Thy1-Tcf4)1Mjro  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-Tcf4)1Mjro expresses 1 gene
Mutation detailsThis transgene consists of the full-length mouse Tcf4 open reading frame under the control of the Thy1.2 minigene, which restricts expression to the postnatal brain. In addition a Flag-tag was added on the N-terminus and a TAP-tag on the C-terminus of Tcf4. qRT-PCR shows approximately 1.5-fold overexpression in the hippocampus and expression in the cortex and amygdala but not in the striatum. Western blotting confirmed protein expression in the cortex and hippocampus but not in the cerebellum and in situ hybridization shows expression in the hippocampus, the neocortex, thalamus, and mesencephalic structures of adults. Western blotting also shows that transgene expression first occurs at postnatal day 2. (J:202664)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:202664 Brzozka MM, et al., Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biol Psychiatry. 2010 Jul 1;68(1):33-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory