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Tg(Thy1-Tcf4)1Mjro
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-Tcf4)1Mjro
Name: transgene insertion 1, Moritz J Rossner
MGI ID: MGI:5521185
Synonyms: Tcf4tg, Tg[Thy-1-Tcf4]1Mr
Transgene: Tg(Thy1-Tcf4)1Mjro  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-Tcf4)1Mjro expresses 1 gene
 
Mutation detailsThis transgene consists of the full-length mouse Tcf4 open reading frame under the control of the Thy1.2 minigene, which restricts expression to the postnatal brain. In addition a Flag-tag was added on the N-terminus and a TAP-tag on the C-terminus of Tcf4. qRT-PCR shows approximately 1.5-fold overexpression in the hippocampus and expression in the cortex and amygdala but not in the striatum. Western blotting confirmed protein expression in the cortex and hippocampus but not in the cerebellum and in situ hybridization shows expression in the hippocampus, the neocortex, thalamus, and mesencephalic structures of adults. Western blotting also shows that transgene expression first occurs at postnatal day 2. (J:202664)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:202664 Brzozka MM, et al., Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biol Psychiatry. 2010 Jul 1;68(1):33-40
All:  2 reference(s)

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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory