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Sema3dtm1.1Joe
Targeted Allele Detail
Nomenclature
Symbol: Sema3dtm1.1Joe
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; targeted mutation 1.1, Jonthan Epstein
MGI ID: MGI:5520920
Gene: Sema3d  Location: Chr5:12383385-12588948 bp, + strand  Genetic Position: Chr5, 3.97 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198676
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA stop cassette and an FRT-flanked neomycin resistance cassette replaced most of exon 2 and the splice donor site. Flp-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expresion in the heart, brain and lung. (J:198676)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema3d Mutation:  3 strains or lines available
References
Original:  J:198676 Degenhardt K, et al., Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nat Med. 2013 Jun;19(6):760-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory