About   Help   FAQ
Tg(Pkd1*)39Mtru
Transgene Detail
Nomenclature
Symbol: Tg(Pkd1*)39Mtru
Name: transgene insertion 39, Marie Trudel
MGI ID: MGI:5519083
Synonyms: Pkd1-extra
Transgene: Tg(Pkd1*)39Mtru  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pkd1*)39Mtru expresses 1 gene
 
Mutation detailsA BAC was modified to truncate murine Pkd1 such that the region just prior to the first transmembrane and the membrane-spanning and intracellular domains is deleted and produces only the extracellular domain. A second modification removed the Tsc2 gene from the BAC. Immunoblotting confirmed protein expression in various tissues including kidney, brain, liver, lung, and spleen. Four lines were generated (2, 9, 11, and 39) with 2 to 85 copies of the transgene. All lines show a similar phenotype. Line 39 is the low expressing line with 2 copies of the transgene. (J:198147)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:198147 Kurbegovic A, et al., Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain. Hum Mol Genet. 2013 Jun 15;22(12):2361-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/06/2019
MGI 6.14
The Jackson Laboratory