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Transgene Detail
Symbol: Tg(Pkd1*)39Mtru
Name: transgene insertion 39, Marie Trudel
MGI ID: MGI:5519083
Synonyms: Pkd1-extra
Transgene: Tg(Pkd1*)39Mtru  Location: unknown  
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Pkd1*)39Mtru expresses 1 gene
Mutation detailsA BAC was modified to truncate murine Pkd1 such that the region just prior to the first transmembrane and the membrane-spanning and intracellular domains is deleted and produces only the extracellular domain. A second modification removed the Tsc2 gene from the BAC. Immunoblotting confirmed protein expression in various tissues including kidney, brain, liver, lung, and spleen. Four lines were generated (2, 9, 11, and 39) with 2 to 85 copies of the transgene. All lines show a similar phenotype. Line 39 is the low expressing line with 2 copies of the transgene. (J:198147)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:198147 Kurbegovic A, et al., Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain. Hum Mol Genet. 2013 Jun 15;22(12):2361-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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