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Cavin3tm1Pemi
Targeted Allele Detail
Nomenclature
Symbol: Cavin3tm1Pemi
Name: caveolae associated 3; targeted mutation 1, Peter Michaely
MGI ID: MGI:5518819
Synonyms: Cavin-3 KO, Prkcdbp-
Gene: Cavin3  Location: Chr7:105480616-105482197 bp, - strand  Genetic Position: Chr7, 55.87 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202374
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a loxP-flanked NEO cassette was used to disrupt exon 1 and most of exon 2. No gene product (protein) is detected by Western blot analysis of MEFs isolated from homozygous animals. (J:202374)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cavin3 Mutation:  6 strains or lines available
References
Original:  J:202374 Hernandez VJ, et al., Cavin-3 dictates the balance between ERK and Akt signaling. Elife. 2013;2:e00905
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory