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Sox11tm1.1Gan
Targeted Allele Detail
Nomenclature
Symbol: Sox11tm1.1Gan
Name: SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
MGI ID: MGI:5518640
Synonyms: Sox11loxP
Gene: Sox11  Location: Chr12:27334264-27342574 bp, - strand  Genetic Position: Chr12, 9.95 cM, cytoband A3
Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199663
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the open reading frame. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the open reading frame. Flp-mediated recombination removed the neomycin resistance cassette and left the open reading frame floxed. (J:199663)
Generation of the Sox11tm1.1Gan allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox11 Mutation:  1 strain or line available
References
Original:  J:199663 Jiang Y, et al., Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013 Jun 21;288(25):18429-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory