Lats1^tm1Shku
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1Shku
• Name: large tumor suppressor; targeted mutation 1, Shinji Kuninaka
• MGI ID: MGI:5518616
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1Shku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185202
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was targeted for deletion by replacement with a neomycin resistance gene cassette. Immunoblot analysis confirmed absence of peptide expression from this knockout allele. (J:185202)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 48 strains or lines available

References

• Original: J:185202 Chiyoda T, et al., LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol. 2012 May 28;197(5):625-41
• All: 5 reference(s)