Adm^tm1Kmca
Targeted Allele Detail

Summary

• Symbol: Adm^tm1Kmca
• Name: adrenomedullin; targeted mutation 1, Kathleen M Caron
• MGI ID: MGI:5517672
• Synonyms: Amd^hi
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1Kmca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201446
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the 3' UTR downstream of the translation stop codon contains a loxP site, the bovine growth hormone polyadenylation sequence, 2 tandem copies of the 1.2-kb 5' insulator sequence from chicken beta-globin gene, neomycin resistance cassette, loxP site and 80 bp of AU/U-rich element of the mouse Fos gene. These modifications stabilize the transcript and result in a 3-fold increase in transcript expression. (J:201446)

Expression

In Mice Carrying this Mutation:

22 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:201446 Li M, et al., Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. J Clin Invest. 2013 Jun 3;123(6):2408-20
• All: 6 reference(s)