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Targeted Allele Detail
Symbol: Npr1tm1.1Rsha
Name: natriuretic peptide receptor 1; targeted mutation 1.1, Rameshwar K Sharma
MGI ID: MGI:5516490
Synonyms: 669WTAPELL675-
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:201932
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 14 was replaced with a floxed neomycin resistance cassette and a modified exon 14 in which the 669WTAPELL675 motif was deleted. This domain is critical for the transduction of the atrial natriuretic peptide signal. Cre-mediated recombination removed the neomycin resistance cassette. (J:201932)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  26 strains or lines available
Original:  J:201932 Duda T, et al., The ANF-RGC gene motif (669)WTAPELL(675) is vital for blood pressure regulation: biochemical mechanism. Biochemistry. 2013 Apr 2;52(13):2337-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory