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Dna2tm1.1Lzhg
Targeted Allele Detail
Nomenclature
Symbol: Dna2tm1.1Lzhg
Name: DNA replication helicase/nuclease 2; targeted mutation 1.1, Li Zheng
MGI ID: MGI:5515895
Gene: Dna2  Location: Chr10:62947026-62974185 bp, + strand  Genetic Position: Chr10, 32.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198831
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exons 4 through 7. Cre-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed reduced protein expression in heterozygous mouse embryonic fibroblasts. (J:198831)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dna2 Mutation:  41 strains or lines available
References
Original:  J:198831 Lin W, et al., Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 2013 May 15;32(10):1425-39
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory