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Targeted Allele Detail
Symbol: Prkar2btm3Gsm
Name: protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 3, G Stanley McKnight
MGI ID: MGI:5515221
Gene: Prkar2b  Location: Chr12:31958476-32061296 bp, - strand  Genetic Position: Chr12, 13.74 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:196157
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neomycin resistance gene and stop signal were inserted in exon 1 about 50 bp upstream of the ATG start codon. cre excision of the inserted sequence restores gene function. (J:196157)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkar2b Mutation:  2 strains or lines available
Original:  J:196157 Zheng R, et al., Deficiency of the RIIbeta subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1631-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory