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Sgpl1tm1.2Npa
Targeted Allele Detail
Summary
Symbol: Sgpl1tm1.2Npa
Name: sphingosine phosphate lyase 1; targeted mutation 1.2, Novartis Pharma AG
MGI ID: MGI:5514382
Synonyms: Sgpl1-
Gene: Sgpl1  Location: Chr10:60934421-60983463 bp, - strand  Genetic Position: Chr10, 32.14 cM
Alliance: Sgpl1tm1.2Npa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199525
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe loxP-flanked exon 8 of Sgpl1 was excised by crossing tm1.1 mice to cre deleter mice, producing a null allele. (J:199525)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgpl1 Mutation:  33 strains or lines available
References
Original:  J:199525 Billich A, et al., Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One. 2013;8(3):e59630
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory