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Tardbptm1.2Cjks
Targeted Allele Detail
Nomenclature
Symbol: Tardbptm1.2Cjks
Name: TAR DNA binding protein; targeted mutation 1.2, C K James Shen
MGI ID: MGI:5513108
Synonyms: Tardbplx
Gene: Tardbp  Location: Chr4:148612382-148627019 bp, - strand  Genetic Position: Chr4, 78.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155958
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 2 and 3 were flanked by loxP sites and an FRT flanked neo cassette and a 29 bp deletion for genotyping were inserted in intron 3 via homologous recombination. The FRT flanked neo cassette was removed by germline expression of flp recombinase. (J:155958, J:190254)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tardbp Mutation:  36 strains or lines available
References
Original:  J:155958 Wu LS, et al., TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010 Jan;48(1):56-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory