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Fgl1tm1Cuko
Targeted Allele Detail
Nomenclature
Symbol: Fgl1tm1Cuko
Name: fibrinogen-like protein 1; targeted mutation 1, Chinweike Ukomadu
MGI ID: MGI:5510996
Gene: Fgl1  Location: Chr8:41644471-41668193 bp, - strand  Genetic Position: Chr8, 23.89 cM
Lipid accumulation in Fgl1tm1Cuko/Fgl1tm1Cuko livers

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199844
Parent Cell Line:  PTL1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exons 2 and 3. Western blot analysis confirmed the absence of protein in the liver. (J:199844)
Schematic representation of the generation of the Fgl1tm1Cuko allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgl1 Mutation:  17 strains or lines available
References
Original:  J:199844 Demchev V, et al., Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One. 2013;8(3):e58084
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory