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Sytl1tm1Tiz
Targeted Allele Detail
Summary
Symbol: Sytl1tm1Tiz
Name: synaptotagmin-like 1; targeted mutation 1, Tetsuro Izumi
MGI ID: MGI:5509384
Gene: Sytl1  Location: Chr4:132980401-132990398 bp, - strand  Genetic Position: Chr4, 66.25 cM
Alliance: Sytl1tm1Tiz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200233
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in islets. (J:200233)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sytl1 Mutation:  27 strains or lines available
References
Original:  J:200233 Wang H, et al., The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol Biol Cell. 2013 Feb;24(3):319-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory