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Tg(LCR-HBA2,LCR-HBB*)1Cos
Transgene Detail
Nomenclature
Symbol: Tg(LCR-HBA2,LCR-HBB*)1Cos
Name: transgene insertion 1, Frank Costantini
MGI ID: MGI:5509327
Synonyms: SAD-1
Transgene: Tg(LCR-HBA2,LCR-HBB*)1Cos  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LCR-HBA2,LCR-HBB*)1Cos expresses 3 genes
 
Mutation detailsConstructs expressing the human alpha2-globin gene from the locus control region of the human beta globin gene and the human hemoglobin beta gene containing the Sickle Antilles mutations (Glu6Val and Val23Ile) and the D Punjab mutation (Glu121Gln) also from the human locus control region were coinjected to create a line of mice with cointegrated transgenes. These three mutations in hemoglobin beta promote the polymerization of hemoglobin. This line contains approximately one copy of the HBB* gene and two copies of the HBA2 gene. (J:94193)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:94193 Trudel M, et al., Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD. EMBO J. 1991 Nov;10(11):3157-65
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory