Tg(LCR-HBA2,LCR-HBB*)1Cos
Transgene Detail

Summary

• Symbol: Tg(LCR-HBA2,LCR-HBB*)1Cos
• Name: transgene insertion 1, Frank Costantini
• MGI ID: MGI:5509327
• Synonyms: SAD-1
• Transgene: Tg(LCR-HBA2,LCR-HBB*)1Cos Location: unknown
• Alliance: Tg(LCR-HBA2,LCR-HBB*)1Cos page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LCR-HBA2,LCR-HBB*)1Cos expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBA2 (3040)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

• Mutation details: Constructs expressing the human alpha2-globin gene from the locus control region of the human beta globin gene and the human hemoglobin beta gene containing the Sickle Antilles mutations (Glu6Val and Val23Ile) and the D Punjab mutation (Glu121Gln) also from the human locus control region were coinjected to create a line of mice with cointegrated transgenes. These three mutations in hemoglobin beta promote the polymerization of hemoglobin. This line contains approximately one copy of the HBB* gene and two copies of the HBA2 gene. (J:94193)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94193 Trudel M, et al., Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD. EMBO J. 1991 Nov;10(11):3157-65
• All: 10 reference(s)