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Tg(T-cre/ERT2)1Lwd
Transgene Detail
Nomenclature
Symbol: Tg(T-cre/ERT2)1Lwd
Name: transgene insertion 1, Mark Lewandoski
MGI ID: MGI:5509185
Synonyms: TCreERT2
Transgene: Tg(T-cre/ERT2)1Lwd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6NCr x C3H/HeNCr)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe cre recombinase coding region fused to the sequence for a mutated ligand-binding domain of the human estrogen receptor was inserted into a construct where it is under the control of the 500 bp brachyury (T) promoter. Eight transgenic lines were generated and one which showed extensive cre activity in presence of tamoxifen but little without tamoxifen induction. (J:200549)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: T     Summary of all recombinase alleles driven by T.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Zygotes for injection were derived by intercrossing B6C3F1 (C57BL/6NCr X C3H/HeNCrMTV) mice.
References
Original:  J:200549 Anderson MJ, et al., TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud. PLoS One. 2013;8(4):e62479
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory