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Tg(UBC-CCR5,-CD4)19Mnz
Transgene Detail
Nomenclature
Symbol: Tg(UBC-CCR5,-CD4)19Mnz
Name: transgene insertion 19, Michel C Nussenzweig
MGI ID: MGI:5509007
Transgene: Tg(UBC-CCR5,-CD4)19Mnz  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(UBC-CCR5,-CD4)19Mnz expresses 2 genes
 
Mutation detailsA transgene composed of human CCR5 and CD4 on a single poly-protein transcript separated by a ribosomal skip 2A was placed downstream of thehuman ubiquitin C promoter. A linearized 4.5 Kb fragment containing the transgene was injected into C57BL/6J fertilized female pronuclei. Founder line 19 was chosen based on surface expression of hCD4 and hCCR5 on peripheral blood mononuclear cells as determined by flow cytometry. (J:200013)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:200013 Gruell H, et al., Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model. J Virol. 2013 Aug;87(15):8535-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory