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Tg(Thy1-VCP*A232E)BMaki
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-VCP*A232E)BMaki
Name: transgene insertion B, Masashi Kitazawa
MGI ID: MGI:5508556
Transgene: Tg(Thy1-VCP*A232E)BMaki  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-VCP*A232E)BMaki expresses 1 gene
 
Mutation detailsThis transgenic construct contains human VCP with the disease-relevant A232E mutation under the control of the forebrain specific Thy1 (Thy1.2) promoter. Two lines were established, A and B. Line B contains 3-4x more copies of the transgene than line A. (J:199083)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:199083 Rodriguez-Ortiz CJ, et al., Neuronal-Specific Overexpression of a Mutant Valosin-Containing Protein Associated with IBMPFD Promotes Aberrant Ubiquitin and TDP-43 Accumulation and Cognitive Dysfunction in Transgenic Mice. Am J Pathol. 2013 Aug;183(2):504-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/08/2019
MGI 6.13
The Jackson Laboratory