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Ezrtm1Sats
Targeted Allele Detail
Nomenclature
Symbol: Ezrtm1Sats
Name: ezrin; targeted mutation 1, Sachiko Tsukita
MGI ID: MGI:5508539
Synonyms: Ez-, Vil2kd
Gene: Ezr  Location: Chr17:6738131-6782780 bp, - strand  Genetic Position: Chr17, 4.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200366
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct inserted into intron 2 a splice acceptor, IRES, lacZ, neomycin resistance cassette and polyadenylation sequence. Immunoblotting confirmed protein expression in small amounts in the stomach. (J:200366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ezr Mutation:  59 strains or lines available
References
Original:  J:200366 Tamura A, et al., Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol. 2005 Apr 11;169(1):21-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory