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Gnao1tm2Rneu
Targeted Allele Detail
Nomenclature
Symbol: Gnao1tm2Rneu
Name: guanine nucleotide binding protein, alpha O; targeted mutation 1, Richard R Neubig
MGI ID: MGI:5508226
Synonyms: GalphaoG184S
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197965
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that result in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. A floxed neo cassette was inserted between the modified exon 5 and exon 6. (J:197965)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
References
Original:  J:197965 Goldenstein BL, et al., Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Mol Pharmacol. 2009 May;75(5):1222-30
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory