About   Help   FAQ
Targeted Allele Detail
Symbol: Gnao1tm2Rneu
Name: guanine nucleotide binding protein, alpha O; targeted mutation 1, Richard R Neubig
MGI ID: MGI:5508226
Synonyms: GalphaoG184S
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:197965
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that result in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. A floxed neo cassette was inserted between the modified exon 5 and exon 6. (J:197965)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
Original:  J:197965 Goldenstein BL, et al., Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Mol Pharmacol. 2009 May;75(5):1222-30
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory