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Ccl2tm1.2Tyos
Targeted Allele Detail
Summary
Symbol: Ccl2tm1.2Tyos
Name: C-C motif chemokine ligand 2; targeted mutation 1.2, Teizo Yoshimura
MGI ID: MGI:5507824
Synonyms: MCP-1flox
Gene: Ccl2  Location: Chr11:81926403-81928278 bp, + strand  Genetic Position: Chr11, 49.82 cM, cytoband C-E1
Alliance: Ccl2tm1.2Tyos page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151874
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsMice containing the floxed Ccl2tm1Tyos allele were crossed with EIIa-Cre mice to remove the floxed neo cassette. These mice retain exons 1 and 2 flanked by loxP sites. (J:151874)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl2 Mutation:  25 strains or lines available
References
Original:  J:151874 Takahashi M, et al., Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol. 2009 Sep 1;183(5):3463-71
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory