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Scn8am10J
Spontaneous Allele Detail
Nomenclature
Symbol: Scn8am10J
Name: sodium channel, voltage-gated, type VIII, alpha; mutation 10 Jackson
MGI ID: MGI:5506774
Gene: Scn8a  Location: Chr15:100869863-101045938 bp, + strand  Genetic Position: Chr15, 56.39 cM, cytoband F1
Mutation
origin
Strain of Origin:  FVB/NJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous C-to-A transversion in chromosome 15 nucleotide 101,013,440 (GRCm38) causes an arginine to serine substitution at amino acid 914 (p.R914S), which is in the ion pore region of domain 2. (J:199990)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn8a Mutation:  20 strains or lines available
References
Original:  J:199990 Schroeder DG, et al., The Scn8a spontaneous point mutation. MGI Direct Data Submission. 2013;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory