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Epg5tm1Ygz
Targeted Allele Detail
Nomenclature
Symbol: Epg5tm1Ygz
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans); targeted mutation 1, Yan G Zhao
MGI ID: MGI:5505596
Gene: Epg5  Location: Chr18:77938465-78035013 bp, + strand  Genetic Position: Chr18, 52.38 cM
Epg5tm1Ygz/Epg5tm1Ygz mice show motor deficits

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196603
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 18 and 19. Western blot analysis confirmed the absence of protein expression. (J:196603)
Generation of the Epg5tm1Ygz allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epg5 Mutation:  0 strains or lines available
References
Original:  J:196603 Zhao H, et al., Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol. 2013 Mar 18;200(6):731-41
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory