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Targeted Allele Detail
Symbol: Mad2l2tm1Ymu
Name: MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Yoshiki Murakumo
MGI ID: MGI:5505390
Synonyms: Rev7-
Gene: Mad2l2  Location: Chr4:148130384-148145699 bp, + strand  Genetic Position: Chr4, 78.67 cM, cytoband E1
Growth retardation and small testis in Mad2l2tm1Ymu/Mad2l2tm1Ymu mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:198275
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced part of exon 1 and exon 2. Western blot analysis confirmed the absence of protein expression the testis, kidney, liver and spleen. (J:198275)
Generation of the Mad2l2tm1Ymu allele
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 54 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mad2l2 Mutation:  5 strains or lines available
Original:  J:198275 Watanabe N, et al., The REV7 subunit of DNA polymerase zeta is essential for primordial germ cell maintenance in the mouse. J Biol Chem. 2013 Apr 12;288(15):10459-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory