Rala^tm1.1Cjm
Targeted Allele Detail

Summary

• Symbol: Rala^tm1.1Cjm
• Name: v-ral simian leukemia viral oncogene A (ras related); targeted mutation 1.1, Christopher J Marshall
• MGI ID: MGI:5505277
• Gene: Rala Location: Chr13:18055160-18118802 bp, - strand Genetic Position: Chr13, 6.05 cM, cytoband A3.1
• Alliance: Rala^tm1.1Cjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199742
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3 and the neomycin resistance cassette. (J:199742)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rala Mutation: 26 strains or lines available

References

• Original: J:199742 Peschard P, et al., Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol. 2012 Nov 6;22(21):2063-8
• All: 2 reference(s)